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Is silicone oil safe?

Is silicone oil safe?

From a physiological point of view, polysiloxane is one of the polymers with the lowest known activity. The results of toxicological studies suggest that dimethyl silicone oil, which removes low-boiling substances, is non-toxic and can be used in large amounts in food,

cosmetics, and pharmaceuticals. The LD50 value (50% lethal amount) of the lethal dose of dimethyl silicone oil is more than 35g/Kg. This value is classified according to the toxicity of the American Industrial Hygiene Association, which is equivalent to non-toxic; it also has no chronic poisoning problems and will not be absorbed by the digestive system. No irritation to the membrane; low viscosity dimethyl silicone oil has slight irritation to the cornea, but no harm.

Safety data of silicone oil as follow:

Types of silicone oil

Viscosity (25°C/mm2Ÿs)

Skin irritation (human)

Chronic toxicity (rat, 6 months)

Acute toxicity LD50 (rat, administered orally)

Eye irritation (Japanese white rabbit)

Methyl hydrogen silicone oil

5

Quasi-negative

---

>33ML/kg

Very slight

10

Negative

No abnormality [input amount 10mL/(kg·d)]

---

---

20

---

---

>50g/kg

---

100

Negative

---

---

---

Methyl phenyl silicone oil (phenyl mole fraction 25%)

20

Quasi-negative

---

>33ML/kg

Very slight

Methylphenyl silicone oil (phenyl mole fraction 50%)

400

---

---

30g/kg

---

Methyl hydrogen silicone oil

---

---

---

>33ML/kg

---

*  No effect on cornea; slight inflammation on conjunctiva, but less irritating than normal detergent.

It should be noted that the production method and production environment of silicone oil affect the purity of silicone oil (including low-molecular-weight siloxanes remaining in the silicone oil, catalyst decomposition, neutralization residues and impurities brought into the production environment). For medicine, food and cosmetics, special grade silicone oil should be used. At present, the country has promulgated the National Food Safety Standard for Food Additives Dimethicone and Its Emulsions (GB 30612-2014). Special grade silicone oil for production license.

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